0000950170-23-018017 Sample Contracts

ULTRAGENYX PHARMACEUTICAL INC. PERFORMANCE STOCK UNIT AGREEMENT (2023)

Performance Stock Unit Agreement • May 5th, 2023 • Ultragenyx Pharmaceutical Inc. • Pharmaceutical preparations

• Contract Type
  Performance Stock Unit Agreement
• Filed
  May 5th, 2023
• Company
  Ultragenyx Pharmaceutical Inc.
• Industry
  Pharmaceutical preparations

This agreement (this “Agreement”) evidences an award (the “Award”) of performance stock units (the “Performance Stock Units”) granted by Ultragenyx Pharmaceutical Inc. (the “Company”) to the undersigned (the “Grantee”) pursuant to and subject to the terms of the Ultragenyx Pharmaceutical Inc. 2014 Incentive Plan (as amended from time to time, the “Plan”), which is incorporated herein by reference.

March 31, 2023 Eric Crombez, M.D. Dear Eric: Re: Amended and Restated Offer of Employment

Offer of Employment • May 5th, 2023 • Ultragenyx Pharmaceutical Inc. • Pharmaceutical preparations

• Contract Type
  Offer of Employment
• Filed
  May 5th, 2023
• Company
  Ultragenyx Pharmaceutical Inc.
• Industry
  Pharmaceutical preparations

On behalf of Ultragenyx Pharmaceutical Inc. (the “Company”), I am pleased to offer you the position of Executive Vice President, Chief Medical Officer (“CMO”), on the following terms, commencing on May 1, 2023 (the “Effective Date”). The terms set forth below will be effective as of the Effective Date. As of the Effective Date, this letter agreement will supersede in its entirety the terms of any employment agreement between you and the Company or its subsidiaries, including without limitation, the terms of the letter agreement dated November 7, 2017 by and between you and Dimension Therapeutics, Inc. (“Dimension”) and the employment agreement effective October 22, 2015 by and between you and Dimension.

May 1, 2023 Camille Bedrosian M.D. Re: Amendment No. 2 to Offer Letter Dear Camille:

Offer Letter • May 5th, 2023 • Ultragenyx Pharmaceutical Inc. • Pharmaceutical preparations

• Contract Type
  Offer Letter
• Filed
  May 5th, 2023
• Company
  Ultragenyx Pharmaceutical Inc.
• Industry
  Pharmaceutical preparations

On behalf of Ultragenyx Pharmaceutical Inc. (the “Company”), I am pleased to present to you this Amendment No. 2 (this “Amendment”), which amends the Offer of Employment Letter Agreement with you dated January 15, 2018, as amended on September 13, 2022 (the “Offer Letter”) pursuant to the terms set forth below. The amended terms set forth below will be effective as of May 1, 2023 (the “Effective Date”).