0000950170-24-127016 Sample Contracts

CONSULTING AGREEMENT
Consulting Agreement • November 14th, 2024 • Spero Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

This Consulting Agreement (the “Agreement”) is dated August 7, 2024, and is effective as of August 29, 2024 (the “Effective Date”) by and between Spero Therapeutics, Inc., with offices located at 675 Massachusetts Avenue, 14th Floor, Cambridge, MA 02139, together with its subsidiaries and affiliates (collectively, “Spero”) and Kamal Hamed (“Consultant”). Spero and Consultant shall be referred to individually as a “Party” and together as the “Parties”.

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AMENDMENT 4 TO Exclusive License Agreement
Exclusive License Agreement • November 14th, 2024 • Spero Therapeutics, Inc. • Pharmaceutical preparations

This Amendment 4 (“Amendment 4”) entered into as of the last date of the signatures below (“Amendment 4 Effective Date”), by and between Spero Therapeutics, Inc. (“Spero”) and GlaxoSmithKline Intellectual Property (No. 3) Limited (“GSK”), hereby amends the Exclusive License Agreement between the Parties dated September 21, 2022, as amended on July 4, 2023 by Amendment 1 to Exclusive License Agreement, and further amended on December 20, 2023 by Amendment 2 to Exclusive License Agreement, and further amended on March 4, 2024 by Amendment 3 to Exclusive License Agreement (the “Agreement”). Capitalized terms not otherwise defined in this Amendment 4 will have the same meanings as ascribed to such terms in the Agreement.

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