0001002637-02-000005 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. AMENDMENT NO. 6 to AGREEMENT by and between BAYER AG AND MILLENNIUM PHARMACEUTICALS, INC.
Millennium Pharmaceuticals Inc • April 30th, 2002 • Pharmaceutical preparations

This is Amendment No. 6 ("Amendment No. 6") dated as of March 22, 2002 (the "Amendment Effective Date"), to the Agreement, dated as of September 22, 1998 (as amended, the "Agreement"), by and between Bayer AG, located at D 51368 Leverkusen, Germany and Millennium Pharmaceuticals, Inc., located at 75 Sidney Street, Cambridge, Massachusetts 02139. The Agreement has previously been amended by Amendment No. 2 dated as of December 1, 1999, Amendment No. 3 dated as of September 18, 2000, Amendment No. 4 dated as of December 1, 2000 and Amendment No. 5 dated as of September 7, 2001. The Parties acknowledge that there is no Amendment No. 1 to this Agreement.

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