0001017491-18-000092 Sample Contracts

REGISTRATION RIGHTS AGREEMENT

Registration Rights Agreement • October 17th, 2018 • Apricus Biosciences, Inc. • Pharmaceutical preparations • New York

• Contract Type
  Registration Rights Agreement
• Filed
  October 17th, 2018
• Company
  Apricus Biosciences, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

REGISTRATION RIGHTS AGREEMENT (this "Agreement"), dated as of October 16, 2018, by and among Apricus Biosciences, Inc., a Nevada corporation, with headquarters located at 11975 El Camino Real, Suite 300, San Diego, California 92130 (the "Company"), and the investors listed on the Schedule of Buyers attached hereto (each, a "Buyer" and collectively, the "Buyers").

SECURITIES PURCHASE AGREEMENT

Securities Purchase Agreement • October 17th, 2018 • Apricus Biosciences, Inc. • Pharmaceutical preparations • New York

• Contract Type
  Securities Purchase Agreement
• Filed
  October 17th, 2018
• Company
  Apricus Biosciences, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

SECURITIES PURCHASE AGREEMENT (this "Agreement"), dated as of October 16, 2018, by and among Seelos Therapeutics, Inc., a Delaware corporation, with headquarters located at 209 Lukes Wood Road, New Canaan, CT 06840 ("Seelos"), Apricus Biosciences, Inc., a Nevada corporation, with headquarters located at 11975 El Camino Real, Suite 300, San Diego, CA 92130 ("Apricus"), and the investors listed on the Schedule of Buyers attached hereto (individually, a "Buyer" and collectively, the "Buyers").

SEELOS THERAPEUTICS, INC.

Lock-Up Agreement • October 17th, 2018 • Apricus Biosciences, Inc. • Pharmaceutical preparations • New York

• Contract Type
  Lock-Up Agreement
• Filed
  October 17th, 2018
• Company
  Apricus Biosciences, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

Amendment No. 1 Agreement and Plan of Merger and Reorganization

Agreement and Plan of Merger and Reorganization • October 17th, 2018 • Apricus Biosciences, Inc. • Pharmaceutical preparations • Delaware

• Contract Type
  Agreement and Plan of Merger and Reorganization
• Filed
  October 17th, 2018
• Company
  Apricus Biosciences, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This Amendment No. 1 to Agreement and Plan of Merger and reorganization (this “Amendment”), is made and entered into as of October 16, 2018, by and among Apricus Biosciences, Inc., a Nevada corporation (“Apricus”), Arch Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of Apricus (“Merger Sub”), and Seelos Therapeutics, Inc., a Delaware corporation (the “Company”). Capitalized terms used herein and not otherwise defined shall have the meanings assigned to such terms in that certain Agreement and Plan of Merger and Reorganization, made and entered as of July 30, 2018, by and among Apricus, Merger Sub and the Company (the “Merger Agreement”).