0001019056-10-001054 Sample Contracts

FIRST AMENDMENT TO SHAREHOLDER TENDER AGREEMENT
Shareholder Tender Agreement • August 23rd, 2010 • Perceptive Advisors LLC • Pharmaceutical preparations

This FIRST AMENDMENT TO SHAREHOLDER TENDER AGREEMENT (the “Amendment”), dated as of August 20, 2010, is executed by Perceptive Life Sciences Master Fund Ltd., a Cayman Islands company (“Shareholder”), Endo Pharmaceuticals Holdings Inc., a Delaware corporation (“Parent”), and West Acquisition Corp., a Delaware corporation and a wholly-owned subsidiary of Parent (“Merger Sub”). Initially capitalized terms used and not defined in this Amendment have the meanings ascribed to them in the Agreement (as defined below).

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