0001019155-05-000222 Sample Contracts

AND HOLDERS OF AMERICAN DEPOSITARY RECEIPTS Amended and Restated Deposit Agreement Dated as of November 6, 1992
Deposit Agreement • September 22nd, 2005 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances) • New York

Amended and Restated Deposit Agreement, dated as of November 6, 19921992, to that certain Deposit Agreement dated as of April 15, 19851985, as further amended and restated as of _____________, 2005 among SENETEK PLC, incorporated under the laws of England (herein called the Issuer), THE BANK OF NEW YORK, a New York banking corporation (herein called the Depositary), and all Owners from time to time of American Depositary Receipts issued hereunder.

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