0001032210-03-000453 Sample Contracts

TARGETED GENETICS CORPORATION THIRD AMENDMENT TO RIGHTS AGREEMENT
Rights Agreement • March 27th, 2003 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances)

This THIRD AMENDMENT TO RIGHTS AGREEMENT (this “Amendment”) is made as of January 23, 2003 by and between Targeted Genetics Corporation, a Washington corporation (the “Company”), and Mellon Investor Services LLC, a New Jersey limited liability company, formerly known as ChaseMellon Shareholder Services L.L.C., as rights agent (the “Rights Agent”).

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Settlement and Termination Agreement
Settlement and Termination Agreement • March 27th, 2003 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances)

Celltech Pharmaceuticals Inc. (formerly known as Medeva Pharmaceuticals Inc.), a corporation organized under the laws of Delaware (“Celltech”) and Medeva Limited (Formerly known as Medeva plc) a company organized under the laws of England (“Medeva”) and an affiliate of Celltech; and

AMENDMENT NO. 1 TO INDUSTRIAL COLLABORATION AGREEMENT
Industrial Collaboration Agreement • March 27th, 2003 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances)

THIS AMENDMENT TO INDUSTRIAL COLLABORATION AGREEMENT is made the 14th day of March, 2003 by and among INTERNATIONAL AIDS VACCINE INITIATIVE, INC., a Delaware not-for-profit corporation with its principal offices at 110 William Street, 27th Floor, New York, New York 10038 (hereinafter referred to as “IAVI”), CHILDREN’S RESEARCH INSTITUTE, a not-for-profit corporation with its principal offices at 700 Children’s Drive, Columbus, Ohio 43205 (hereinafter referred to as “Children’s”), and TARGETED GENETICS CORPORATION, a Washington corporation with its principal offices at 1100 Olive Way, Suite 100, Seattle, Washington 98101 (hereinafter referred to as “TGC”).

AMENDMENT NO. 1 TO PRODUCT, DEVELOPMENT AND SUPPLY AGREEMENT
Development and Supply Agreement • March 27th, 2003 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances) • New York

This First Amendment (the “Amendment”) to the Product Development Agreement between Genetics Institute, Inc. and Targeted Genetics Corporation dated as of November 9, 2000 (the “Agreement”) is by and between Genetics Institute LLC, formerly known as Genetics Institute, Inc. (“GI”) and Targeted Genetics Corporation (“TGC”) and is dated as of February 24, 2003.

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