0001035704-05-000736 Sample Contracts

STOCK PURCHASE AGREEMENT
Stock Purchase Agreement • December 16th, 2005 • Biocryst Pharmaceuticals Inc • Biological products, (no disgnostic substances) • Delaware

This STOCK PURCHASE AGREEMENT (this “Agreement”) is entered into as of December 14, 2005 by and among BioCryst Pharmaceuticals, Inc., a Delaware corporation (together with its successors and permitted assigns, the “Issuer”) and the investors named on the signature pages hereto (together with their successors and permitted assigns, the “Investors”). Capitalized terms used but not otherwise defined herein shall have the meanings set forth in Section 6.1.

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NOMINATION AND OBSERVER AGREEMENT
Nomination and Observer Agreement • December 16th, 2005 • Biocryst Pharmaceuticals Inc • Biological products, (no disgnostic substances) • Delaware

This NOMINATION AND OBSERVER AGREEMENT is entered into as of December 16, 2005, by and among BioCryst Pharmaceuticals, Inc., a Delaware corporation, (the “Company”), and Kleiner Perkins Caufield & Byers Holdings, LLC, a Delaware limited liability company (“KPCB”).

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