0001035704-07-000246 Sample Contracts

Alexza Pharmaceuticals, Inc.. and , As Warrant Agent FORM OF COMMON STOCK WARRANT AGREEMENT Dated As Of
Warrant Agreement • April 2nd, 2007 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations • New York

Common Stock Warrant Agreement, dated as of between Alexza Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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ALEXZA PHARMACEUTICALS, INC. and , As Warrant Agent FORM OF DEBT SECURITIES WARRANT AGREEMENT Dated As Of
Warrant Agreement • April 2nd, 2007 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations • New York

Debt Securities Warrant Agreement, dated as of between Alexza Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

ALEXZA PHARMACEUTICALS, INC., Issuer AND Trustee INDENTURE Dated As Of Subordinated Debt Securities
Indenture • April 2nd, 2007 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations • New York

Whereas, for its lawful corporate purposes, the Company has duly authorized the execution and delivery of this Indenture to provide for the issuance of subordinated debt securities (hereinafter referred to as the “Securities”), in an unlimited aggregate principal amount to be issued from time to time in one or more series as in this Indenture provided, as registered Securities without coupons, to be authenticated by the certificate of the Trustee;

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