0001047469-03-026104 Sample Contracts

GTC BIOTHERAPEUTICS, INC. SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 4th, 2003 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York

This Securities Purchase Agreement (the "Agreement") is dated as of July 30, 2003 by and among GTC Biotherapeutics, Inc., a Massachusetts corporation (the "Company"), and the Purchasers listed on the Schedule of Purchasers attached hereto as Exhibit A (individually, a "Purchaser," and collectively, the "Purchasers").

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COMMON STOCK PURCHASE WARRANT To Purchase Shares of Common Stock of GTC Biotherapeutics, Inc.
GTC Biotherapeutics Inc • August 4th, 2003 • Biological products, (no disgnostic substances) • New York

This Common Stock Purchase Warrant (this "Warrant") certifies that, for value received, and any permitted assignee (the "Holder"), is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after August 1, 2003 (the "Initial Exercise Date") and on or prior to the close of business on the fifth anniversary of the Initial Exercise Date (the "Termination Date") but not thereafter, to subscribe for and purchase from GTC Biotherapeutics, Inc., a corporation incorporated in the Commonwealth of Massachusetts (the "Company"), up to shares (the "Warrant Shares") of the Company's Common Stock, par value $0.01 per share (the "Common Stock"). The purchase price of one share of Common Stock (the "Exercise Price") under this Warrant shall be $3.30, subject to adjustment hereunder. The Exercise Price and the number of Warrant Shares for which the Warrant is exercisable shall be subject to adjustment as provided herein. Capitalize

GTC BIOTHERAPEUTICS, INC. REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 4th, 2003 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • New York

This Registration Rights Agreement (this "Agreement") is entered into as of July 30, 2003 by and among GTC Biotherapeutics, Inc., a Massachusetts corporation (the "Company"), and the investors signatory hereto (each, a "Purchaser" and, collectively, the "Purchasers").

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