0001047469-03-027243 Sample Contracts

CHIRON CORPORATION AMENDED AND RESTATED BYLAWS INDEX
Chiron Corp • August 12th, 2003 • Pharmaceutical preparations
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CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. BLOOD SCREENING HCV PROBE LICENSE AGREEMENT— EUROPEAN UNION between CHIRON...
Chiron Corp • August 12th, 2003 • Pharmaceutical preparations

This agreement (hereinafter "Agreement") is made by and between CHIRON CORPORATION, a Delaware corporation, of 4560 Horton Street, Emeryville, California 94608 (hereinafter referred to as "CHIRON"), F. HOFFMANN-LA ROCHE LTD., a Swiss corporation, of Grenzacherstrasse 124, Basel, Switzerland (hereinafter referred to as "ROCHE PARENT"), and ROCHE MOLECULAR SYSTEMS, INC., a Delaware corporation, of 1145 Atlantic Avenue, Suite 100, Alameda, California 94501 (hereinafter referred to as "RMS" and collectively with ROCHE PARENT, "ROCHE").

NOVARTIS AG WRITTEN CONSENT AND APPROVAL Effective as of May 16, 2003
Chiron Corp • August 12th, 2003 • Pharmaceutical preparations

WHEREAS, Sections 2.04 (a)(iv) and (v) of that certain Governance Agreement dated as of November 20, 1994 between Chiron Corporation ("Chiron" or the "Company") and Novartis AG, as amended, requires the approval of Novartis to change the size or composition of the Board of Directors or any committee thereof, and approve any amendment to the Bylaws of the Company;

HCV PROBE LICENSE AND OPTION AGREEMENT— EUROPEAN UNION
License and Option Agreement • August 12th, 2003 • Chiron Corp • Pharmaceutical preparations

This agreement (hereinafter "Agreement") is made by and between CHIRON CORPORATION, a Delaware corporation, of 4560 Horton Street, Emeryville, California 94608 (hereinafter referred to as "CHIRON"), F. HOFFMANN-LA ROCHE LTD., a Swiss corporation, of Grenzacherstrasse 124, Basel, Switzerland (hereinafter referred to as "ROCHE PARENT"), and ROCHE MOLECULAR SYSTEMS, INC., a Delaware corporation, of 1145 Atlantic Avenue, Suite 100, Alameda, California 94501 (hereinafter referred to as "RMS" and collectively with ROCHE PARENT, "ROCHE").

CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. CONTRACT MANUFACTURING AGREEMENT
Contract Manufacturing Agreement • August 12th, 2003 • Chiron Corp • Pharmaceutical preparations

THIS CONTRACT MANUFACTURING AGREEMENT (the "Agreement") is made and entered into as of June 12, 2003 ("Date of Agreement"), by and between:

CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. HIV PROBE LICENSE AND OPTION AGREEMENT—EUROPEAN UNION between CHIRON...
License and Option Agreement • August 12th, 2003 • Chiron Corp • Pharmaceutical preparations

This agreement (hereinafter "Agreement") is made by and between CHIRON CORPORATION, a Delaware corporation, of 4560 Horton Street, Emeryville, California 94608 (hereinafter referred to as "CHIRON"), F. HOFFMANN-LA ROCHE LTD., a Swiss corporation, of Grenzacherstrasse 124, Basel, Switzerland (hereinafter referred to as "ROCHE PARENT"), and ROCHE MOLECULAR SYSTEMS, INC., a Delaware corporation, of 1145 Atlantic Avenue, Suite 100, Alameda, California 94501 (hereinafter referred to as "RMS" and collectively with ROCHE PARENT, "ROCHE").

SECOND AMENDMENT
Lease Agreement • August 12th, 2003 • Chiron Corp • Pharmaceutical preparations

This SECOND AMENDMENT (this "Amendment") is made as of July 1, 2003 by and between BNP PARIBAS LEASING CORPORATION, a Delaware corporation (as successor in interest to BNP Leasing Corporation) ("BNPLC"), and CHIRON CORPORATION, a Delaware corporation ("Chiron").

CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. FDA COMPLIANCE AGREEMENT
Fda Compliance Agreement • August 12th, 2003 • Chiron Corp • Pharmaceutical preparations

Chiron Behring GmbH & Co, with its registered offices at Emil von Behring Strasse 76, 35041 Marburg, Germany, together with Chiron S.r.l., hereafter referred to as "Chiron";

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