0001047469-04-033319 Sample Contracts

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Research Collaboration and License Agreement • November 8th, 2004 • Nitromed Inc • Pharmaceutical preparations

As we have discussed, Merck Frosst Canada & Co. ("Merck") and NitroMed, Inc ("NitroMed") have mutually agreed to terminate the Research Collaboration and License Agreement dated December 12, 2002 (the "Agreement"). The termination is related to Merck's voluntary worldwide withdrawal of VIOXX and the termination of the Phase II clinical trial of NO-VIOXX due to safety issues with VIOXX.

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Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. Publicis Selling Solutions, Inc. 2000 Lenox Drive, Suite 100 Lawrenceville, NJ 08648 Tel: 609-219-0081 Fax: 609-219-9188...
Professional Detailing Services Agreement • November 8th, 2004 • Nitromed Inc • Pharmaceutical preparations • Massachusetts

PROFESSIONAL DETAILING SERVICES AGREEMENT, dated as of November 5, 2004, between PUBLICIS SELLING SOLUTIONS, INC. ("PSS"), a New Jersey corporation with offices at 2000 Lenox Drive, Suite 100, Lawrenceville, New Jersey 08648 and NitroMed, Inc. ("Client"), a Delaware corporation with offices at 125 Spring Street, Lexington, MA 02421-7801.

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