0001047469-05-005469 Sample Contracts

ALLOS THERAPEUTICS, INC. REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • March 4th, 2005 • Allos Therapeutics Inc • Pharmaceutical preparations • Delaware

WHEREAS, the Investors have, pursuant to the terms of the Securities Purchase Agreement, dated as of March 2, 2005, by and among the Company and the Investors (the “Purchase Agreement”), agreed to purchase shares of Series A Exchangeable Preferred Stock, par value $0.001 per share, of the Company (the “Exchangeable Preferred Stock”); and

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SECURITIES PURCHASE AGREEMENT BY AND BETWEEN THE INVESTORS LISTED ON THE SIGNATURE PAGES HERETO AND ALLOS THERAPEUTICS, INC. MARCH 2, 2005
Securities Purchase Agreement • March 4th, 2005 • Allos Therapeutics Inc • Pharmaceutical preparations • Delaware

Allos Therapeutics, Inc., a Delaware corporation (the “Company”), hereby agrees with each of the Investors (each an “Investor” and collectively the “Investors”) listed on the signature pages to this Securities Purchase Agreement, dated as of March 2, 2005 (this “Agreement”), as follows:

February 24, 2005
Letter Agreement • March 4th, 2005 • Allos Therapeutics Inc • Pharmaceutical preparations • New York

This letter agreement (the “Agreement”) amends and restates in its entirety the letter agreement dated December 15, 2004 (the “Prior Agreement”) between Needham & Company, Inc. (“Needham & Company”) and Allos Therapeutics, Inc. (the “Company”). This Agreement confirms the understanding and agreement between Needham & Company and the Company as follows:

AMENDMENT TO RIGHTS AGREEMENT
Rights Agreement • March 4th, 2005 • Allos Therapeutics Inc • Pharmaceutical preparations

THIS AMENDMENT (the “Amendment”), dated as of the 4th day of March, 2005, to the Rights Agreement (the “Rights Agreement”), dated May 6, 2003, between ALLOS THERAPEUTICS, INC., a Delaware corporation (the “Company”) and MELLON INVESTOR SERVICES LLC (the “Rights Agent”), is being executed at the direction of the Company. Capitalized terms used in this Amendment and not otherwise defined herein shall have the meanings given them in the Rights Agreement.

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