0001047469-05-016152 Sample Contracts

GENTIUM, S.P.A. 2,700,000 ORDINARY SHARES UNDERWRITING AGREEMENT New York, New York

Underwriting Agreement • May 31st, 2005 • Gentium S.p.A. • Pharmaceutical preparations • New York

• Contract Type
  Underwriting Agreement
• Filed
  May 31st, 2005
• Company
  Gentium S.p.A.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

AMENDMENT NO. 1 TO GENTIUM S.P.A. SERIES A SENIOR CONVERTIBLE PROMISSORY NOTES, WARRANTS, SUBSCRIPTION AGREEMENTS AND INVESTOR RIGHTS AGREEMENTS

Gentium S.p.A. • May 31st, 2005 • Pharmaceutical preparations • New York

• Company
  Gentium S.p.A.
• Filed
  May 31st, 2005
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Amendment No. 1 (this "Amendment") is dated as of May 27, 2005 among Gentium S.p.A. ("Gentium") and a majority-in-interest of the Holders (as defined below).