0001047469-07-001495 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • February 28th, 2007 • Helicos Biosciences Corp • Delaware

This Agreement made and entered into this day of 2007 (the "Agreement"), by and between Helicos BioSciences Corporation, a Delaware corporation (the "Company," which term shall include, where appropriate, any Entity (as hereinafter defined) controlled directly or indirectly by the Company) and (the "Indemnitee"):

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AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • February 28th, 2007 • Helicos Biosciences Corp • Delaware

WHEREAS, the Series B Investors have entered into a Series B Preferred Stock Purchase Agreement dated as of the date hereof, by and among the Series B Investors and the Company (the "Purchase Agreement") to purchase an aggregate of up to Thirty-One Million Seven Thousand Seven Hundred Fifty-Two (31,007,752) shares of Series B Preferred Stock in one or more closings;

MASTER SECURITY AGREEMENT dated as of June 9, 2006 ("Agreement")
Master Security Agreement • February 28th, 2007 • Helicos Biosciences Corp

THIS AGREEMENT is between General Electric Capital Corporation (together with its successors and assigns, if any, "Secured Party") and Helicos BioSciences Corporation ("Debtor"). Secured Party has an office at 83 Wooster Heights Road, Danbury, CT 06810. Debtor is a corporation organized and existing under the laws of the state of Delaware ("the State"). Debtor's mailing address and chief place of business is One Kendall Square, Building 200, Cambridge, MA 02139.

LICENSE AGREEMENT between ROCHE DIAGNOSTICS GMBH, Sandhoferstr. 116, D-68305 Mannheim Germany and ROCHE DIAGNOSTICS CORPORATION, 9115 Hague Road, Indianapolis, IN 46250-0547, USA (hereinafter collectively referred to as "ROCHE") on the one hand and...
License Agreement • February 28th, 2007 • Helicos Biosciences Corp

ROCHE is the owner of [***] and any foreign applications or patents claiming priority thereto, including but not limited to U.S. Patent [***] and any continuation, continuation-in-part, divisional, and foreign patent applications (and corresponding issued patents) relating to a method for sequencing DNA. HELICOS is interested in obtaining access to this technology and ROCHE is willing to grant to HELICOS a semi-exclusive deblocking license, subject only to the Existing License, under its aforementioned patent rights in order to allow HELICOS to market products for analyzing a target polynucleotide sequence on a support.

LICENSE AGREEMENT
License Agreement • February 28th, 2007 • Helicos Biosciences Corp • California

THIS AGREEMENT is effective as of the day of , 2003 (the "Effective Date"), between CALIFORNIA INSTITUTE OF TECHNOLOGY, 1200 East California Boulevard, Pasadena, CA 91125 ("Caltech") and Helicos BioSciences Corp. ("Licensee"), a corporation having a place of business at 150 CambridgePark Drive, Cambridge, MA 02140.

LICENSE AGREEMENT between Arizona Technology Enterprises, The Brickyard—Suite 601 699 S. Mill Avenue Room 691AA Tempe, AZ 85281 (hereinafter referred to as "AZTE") and HELICOS BIOSCIENCES CORPORATION, One Kendall Square, Building 200, Cambridge, MA...
License Agreement • February 28th, 2007 • Helicos Biosciences Corp

AZTE is the sole and exclusive licensee of the patent and patent applications listed in the attached Appendix A. HELICOS desires to license such patent and patent applications and AZTE desires to grant a license to HELICOS. Accordingly, AZTE and HELICOS agree as follows:

CUMMINGS PROPERTIES, LLC STANDARD FORM COMMERCIAL LEASE
Commercial Lease • February 28th, 2007 • Helicos Biosciences Corp • Massachusetts

In consideration of the covenants herein, Cummings Properties, LLC ("LESSOR") hereby leases to Helicos Biosciences Corporation (a DE corp.), one Kendall Square, Building 200, Cambridge, MA 02139 ("LESSEE") the following premises, approximately 6,230 square feet at 6-C Gill Street, Woburn, MA 01801 ("the leased premises"), for a term of one (1) year commencing at noon on February 1, 2006 and ending at noon on January 30, 2007 unless sooner terminated as herein provided. LESSOR and LESSEE now covenant and agree that the following terms and conditions shall govern this lease.

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