0001047469-07-002854 Sample Contracts

LICENSE AGREEMENT
License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • New York

General. When used in this Agreement, each of the following terms, whether used in the singular or plural, will have the meanings set forth in this Article I. Capitalized terms not defined herein may be defined in the CRT Agreement, as specifically referenced in the context of the sentence applying such capitalized term(s).

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LICENSE AGREEMENT
License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • New York

General. When used in this Agreement, each of the following terms, whether used in the singular or plural, will have the meanings set forth in this Article I.

QUARK BIOTECH, INC.
Stock Option Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

Unless otherwise defined herein, the terms defined in the Plan shall have the same defined meanings in this Option Agreement.

EXCLUSIVE LICENSE AGREEMENT “ISOLATION AND APPLICATION OF P53 INHIBITORS TO CONTROLLING TISSUE RESPONSE TO A VARIETY OF STRESSES AND FACILITATING ANTI- CANCER TREATMENT” (UIC Tech ID #CS01)
Exclusive License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • Illinois

This EXCLUSIVE LICENSE AGREEMENT is effective on the date last subscribed below (the “Effective Date”), and is by and between THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic of the State of Illinois (“UNIVERSITY”) with offices in Chicago, Illinois 60612, and QUARK BIOTECH, INC., a California corporation with principal offices at 1059 Serpentine Lane, Pleasanton, California 94566, (“QBI”).

AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations

This Amendment to the Collaboration Agreement (“Amendment”) is made as of May 25, 2006 (“Effective Date”) by and between Quark Biotech, Inc., a private limited company incorporated under the laws of California with a principal office at 6540 Kaiser Drive, Fremont, California 94555 (hereinafter “Quark”) and QBI Enterprises Ltd., a private company incorporated under the laws of the State of Israel with a principal office at Weizmann Science Park, P.O. Box 4071, Nes Ziona 70400, Israel (together hereinafter “QBI”), and Atugen AG, a company incorporated under the laws of Germany with a registered office at Robert-Rössle-Strasse 10, D-13125 Berlin, Germany (“Atugen”).

LICENSE AGREEMENT BY AND BETWEEN QUARK BIOTECH INC. AND
License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • New York

This License Agreement (this “Agreement”), dated as of September 25, 2006, is by and between Quark Biotech Inc., a California corporation with offices located at 6536 Kaiser Avenue, Fremont, California 94555, U.S.A. (“Quark”) and Pfizer Inc., a Delaware corporation with offices located at 235 East 42nd Street, New York, New York, 10017, U.S.A. (“Pfizer”).

COLLABORATION AGREEMENT
Collaboration Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations

atugen AG, a company incorporated under the laws of Germany, whose registered office is at Robert-Rössle-Str. 10, D13125 Berlin, Germany (hereinafter “Atugen”), of the first Part; and

FIRST AMENDMENT TO THE LICENSE AGREEMENT BETWEEN THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS AND QUARK BIOTECHNOLOGY, INC.
The Exclusive License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations

THIS FIRST AMENDMENT TO THE EXCLUSIVE LICENSE AGREEMENT (the “First Amendment”) is made and entered into as of March 23, 2007 (“Amendment Date”) by and between THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic of the State of Illinois, 1737 W. Polk St., Chicago, IL 60612 (“UNIVERSITY”) and QUARK BIOTECH, INC a California corporation, with a principal place of business at 6536 Kaiser Drive, Fremont, CA 94555 (“LICENSEE”).

LICENSE AGREEMENT
License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

THIS LICENSE AGREEMENT (the “Agreement”) is made as of December 17, 2004 by and between QUARK BIOTECH, INC., a California corporation having its principal place of business at 6536 Kaiser Drive, Fremont CA 94555, U.S.A. (hereinafter referred to as “Quark”) and SANWA KAGAKU KENKYUSHO CO., LTD., a corporation organized and existing under the laws of Japan and having its principal place of business at 35 Higashisotobori-cho, Higashi-ku, Nagoya 461-8631, Japan (hereinafter referred to as “SKK”).

Option and Licence Agreement
Quark Biotech Inc • April 16th, 2007 • Pharmaceutical preparations

Atugen AG, a company incorporated under the laws of Germany, whose registered office is at Robert-Rössle-Str. 10, D13125 Berlin, Germany of the first Part;

QUARK BIOTECH, INC. AT WILL EMPLOYMENT AGREEMENT
Employment Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

THIS EMPLOYMENT AGREEMENT (THE “AGREEMENT”) is made as of November 13, 2006 by and between Quark Biotech, Inc., a California corporation (the “Company”), and Smadar Shakked (the Employee”),

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