0001047469-08-003302 Sample Contracts

SIRTRIS PHARMACEUTICALS, INC. Amended and Restated 2004 Incentive Plan Restricted Stock Award Agreement
Restricted Stock Award Agreement • March 24th, 2008 • Sirtris Pharmaceuticals, Inc. • Pharmaceutical preparations

The undersigned (i) acknowledges that he has received an award (the “Award”) of restricted stock from Sirtris Pharmaceuticals, Inc. (the “Company”) under the Amended and Restated 2004 Incentive Plan (the “Plan”), subject to the terms set forth below and in the Plan; (ii) further acknowledges receipt of a copy of the Plan as in effect on the date hereof; and (iii) agrees with the Company as follows:

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AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • March 24th, 2008 • Sirtris Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT dated as of January 3, 2008 (the “Agreement”) is by and between Sirtris Pharmaceuticals, Inc. (the “Company”), a Delaware corporation with its principal place of business at 200 Technology Square, Cambridge, Massachusetts, and Christoph Westphal (the “Executive”).

SIRTRIS PHARMACEUTICALS, INC.
Sirtris Pharmaceuticals, Inc. • March 24th, 2008 • Pharmaceutical preparations

Thank you for agreeing to become a consultant to Sirtris Pharmaceuticals, Inc. (the “Company”). This letter is to confirm our understanding with respect to the services the Company will ask of you, the compensation you will receive in return and certain related matters. We have agreed as follows.

SIRTRIS PHARMACEUTICALS, INC. Amended and Restated 2004 Incentive Plan Restricted Stock Award Agreement
Restricted Stock Award Agreement • March 24th, 2008 • Sirtris Pharmaceuticals, Inc. • Pharmaceutical preparations

The undersigned (i) acknowledges that he has received an award (the “Award”) of restricted stock from Sirtris Pharmaceuticals, Inc. (the “Company”) under the Amended and Restated 2004 Incentive Plan (the “Plan”), subject to the terms set forth below and in the Plan; (ii) further acknowledges receipt of a copy of the Plan as in effect on the date hereof; and (iii) agrees with the Company as follows:

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