0001047469-08-003889 Sample Contracts

SEPARATION AGREEMENT AND WAIVER AND RELEASE OF ALL CLAIMS
Separation Agreement • April 1st, 2008 • Clarient, Inc • Laboratory analytical instruments • California

This Separation Agreement and Waiver and Release of all Claims ("Agreement") is made and entered into by and between Clarient, Inc. (the "Company"), and Heather Creran ("Executive" or "Employee"), who is currently serving as the Executive Vice-President and Chief Operating Officer—Laboratory Services, in connection with the termination of employment of the Executive.

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FIRST AMENDMENT TO AMENDED AND RESTATED REIMBURSEMENT AND INDEMNITY AGREEMENT
Reimbursement and Indemnity Agreement • April 1st, 2008 • Clarient, Inc • Laboratory analytical instruments • Pennsylvania

This First Amendment to Amended and Restated Reimbursement and Indemnity Agreement (this "Amendment") is entered into as of March 6, 2007, by and among CLARIENT, INC., a Delaware corporation ("Clarient"), SAFEGUARD DELAWARE, INC., a Delaware corporation ("SDI") and SAFEGUARD SCIENTIFICS (DELAWARE), INC., a Delaware corporation ("SSI", and together with SDI, "Safeguard").

AFFIRMATION OF GUARANTY
Affirmation of Guaranty • April 1st, 2008 • Clarient, Inc • Laboratory analytical instruments

This AFFIRMATION OF GUARANTY is made as of February 28, 2008 ("Affirmation"), by and among SAFEGUARD DELAWARE, INC. ("SDI"), SAFEGUARD SCIENTIFICS (DELAWARE), INC. ("SSI"; collectively with SDI, "Guarantors", each, a "Guarantor") and COMERICA BANK ("Bank").

SECOND AMENDMENT TO AMENDED AND RESTATED LOAN AGREEMENT
Loan Agreement • April 1st, 2008 • Clarient, Inc • Laboratory analytical instruments

This Second Amendment to Amended and Restated Loan Agreement is entered into as of March 21, 2008 (the "Amendment") by and between COMERICA BANK ("Bank") and CLARIENT, INC. ("Borrower").

CLARIENT, INC. AMENDED AND RESTATED LOAN AGREEMENT
Loan Agreement • April 1st, 2008 • Clarient, Inc • Laboratory analytical instruments • California

THIS INSTRUMENT OR CERTIFICATE AND THE RIGHTS EVIDENCED HEREBY ARE SUBJECT TO THE TERMS OF THAT CERTAIN SUBORDINATION AGREEMENT, DATED SEPTEMBER 29, 2006, AMONG CLARIENT, INC., CLARIENT DIAGNOSTIC SERVICES, INC. CLRT ACQUISITION, LLC, GENERAL ELECTRIC CAPITAL CORPORATION AND COMERICA BANK, AS AMENDED, RESTATED, SUPPLEMENTED OR OTHERWISE MODIFIED FROM TIME TO TIME, AND ANY TRANSFEREE BY ACCEPTANCE OF SUCH TRANSFER AGREES TO BE BOUND BY THE TERMS THEREBY.

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