0001047469-09-002008 Sample Contracts

LOAN AGREEMENT BETWEEN AMYLIN PHARMACEUTICALS, INC. AND ELI LILLY AND COMPANY
Loan Agreement • February 27th, 2009 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS LOAN AGREEMENT (the “Loan Agreement”) is made as of this 16th day of October, 2008 by and between AMYLIN PHARMACEUTICALS, INC., a Delaware corporation, having a principal place of business at 9360 Towne Center Drive, San Diego, California 92121 (“Amylin”), and ELI LILLY AND COMPANY, an Indiana corporation having a principal place of business at Lilly Corporate Center, Indianapolis, Indiana 46285 (“Lilly”).

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AMENDMENT TO THE COMMERCIAL SUPPLY AGREEMENT
Commercial Supply Agreement • February 27th, 2009 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations

THIS AMENDMENT TO THE COMMERCIAL SUPPLY AGREEMENT (the “Amendment”) is made and entered into effective as of December 8, 2008 (the “Amendment Date”), by and between Amylin Pharmaceuticals, Inc. (“Amylin”) and Baxter Pharmaceutical Solutions LLC (“Baxter”). Capitalized terms used in this Amendment that are not otherwise defined herein shall have the meanings ascribed to such terms in the Agreement (as defined herein).

EXENATIDE ONCE WEEKLY SUPPLY AGREEMENT
Exenatide Once Weekly Supply Agreement • February 27th, 2009 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations • New York

This EXENATIDE ONCE WEEKLY SUPPLY AGREEMENT (“Agreement”) is entered into as of October 16, 2008, by and between Amylin Pharmaceuticals, Inc. (“Amylin”), a Delaware corporation, and Eli Lilly and Company (“Lilly”), a corporation organized and existing under the laws of the State of Indiana. Amylin and Lilly are sometimes referred to herein individually as a “Party” and collectively as “Parties”. References to “Amylin” and “Lilly” and “Party” or “Parties” shall include their respective Affiliates.

AMENDMENT TO THE AMENDED AND RESTATED COMMERCIAL SUPPLY AGREEMENT
Commercial Supply Agreement • February 27th, 2009 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations

This AMENDMENT TO THE AMENDED AND RESTATED COMMERCIAL SUPPLY AGREEMENT (the “Amendment”) is made, entered into, and effective as of January 23, 2009 (the “Amendment Date”), by and between Amylin Pharmaceuticals, Inc. (“Company”) and Wockhardt UK (Holdings) Ltd, formerly CP Pharmaceuticals Ltd. (“Manufacturer”). Capitalized terms used in this Amendment that are not otherwise defined herein shall have the meanings ascribed to such terms in the Agreement (as defined herein).

FIRST AMENDMENT
First Amendment • February 27th, 2009 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS FIRST AMENDMENT dated as of October 27, 2008 (this “Amendment”), among AMYLIN PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), each of the Company’s subsidiaries listed on the signature pages hereto (collectively, together with the Company, the “Borrowers” and each a “Borrower”), the Lenders (as defined below) party hereto, and BANK OF AMERICA, N.A., as Administrative Agent, Collateral Agent and L/C Issuer (in such capacity, the “Administrative Agent”) for the Lenders.

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