0001047469-09-002539 Sample Contracts

December 17, 2008 Sarah P. Cecil c/o Metabolix, Inc. Cambridge, MA 02139 Re: Change of Control Severance Agreement Dear Sarah:
Metabolix, Inc. • March 12th, 2009 • Miscellaneous plastics products • Massachusetts

Metabolix, Inc. (the “Company”) believes that it is in the best interests of the Company to provide you with certain severance benefits in the event of a termination of your employment in connection with a Change of Control, in order to provide you with financial security and sufficient encouragement to remain with the Company notwithstanding the possibility of a Change of Control (as defined below).

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December 17, 2008 Dr. Oliver Peoples c/o Metabolix, Inc. Cambridge, MA 02139 Re: First Amendment to Employment Agreement Dear Oliver:
Employment Letter Agreement • March 12th, 2009 • Metabolix, Inc. • Miscellaneous plastics products

This letter amends the terms of the Employment Letter Agreement (the “Agreement”) dated as of July 20, 2006 by and between Metabolix, Inc. (the “Company”) and you as set forth below. Capitalized terms not defined herein shall have the meaning specified in the Agreement.

December 17, 2008 Richard P. Eno c/o Metabolix, Inc. Cambridge, MA 02139 Re: First Amendment to Employment Agreement Dear Richard:
Employment Letter Agreement • March 12th, 2009 • Metabolix, Inc. • Miscellaneous plastics products

This letter amends the terms of the Employment Letter Agreement (the “Agreement”) dated as of February 20, 2008, by and between Metabolix, Inc. (the “Company”) and you, as set forth below. Capitalized terms not defined herein shall have the meaning specified in the Agreement.

February 6, 2009 Dr. Oliver Peoples c/o Metabolix, Inc. Cambridge, MA 02139 Re: Second Amendment to Employment Agreement Dear Oliver:
Employment Letter Agreement • March 12th, 2009 • Metabolix, Inc. • Miscellaneous plastics products

This letter amends the terms of the Employment Letter Agreement (the “Agreement”) dated as of July 20, 2006 by and between Metabolix, Inc. (the “Company”) and you, as previously amended, as set forth below. Capitalized terms not defined herein shall have the meaning specified in the Agreement.

Re: Employment Agreement
Metabolix, Inc. • March 12th, 2009 • Miscellaneous plastics products • Massachusetts

This letter is to confirm our understanding with respect to your employment by Metabolix, Inc. (the “Company”). The terms and conditions agreed to in this letter are hereinafter referred to as the “Agreement.” In consideration of the mutual promises and covenants contained in this Agreement, and for other good and valuable consideration, the receipt and sufficiency of which are hereby mutually acknowledged, we have agreed as follows:

December 17, 2008 Joseph Hill c/o Metabolix, Inc. Cambridge, MA 02139 Re: First Amendment to Employment Agreement Dear Joe:
Employment Letter Agreement • March 12th, 2009 • Metabolix, Inc. • Miscellaneous plastics products

This letter amends the terms of the Employment Letter Agreement (the “Agreement”) dated as of March 14, 2008, by and between Metabolix, Inc. (the “Company”) and you as set forth below. Capitalized terms not defined herein shall have the meaning specified in the Agreement.

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