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0001047469-10-000489 Sample Contracts

LICENSE AGREEMENT by and between IRONWOOD PHARMACEUTICALS, INC. and ASTELLAS PHARMA INC. November 10, 2009
License Agreement • February 2nd, 2010 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS LICENSE AGREEMENT (the “Agreement”) is entered into on this 10th day of November, 2009 (the “Effective Date”), by and among Ironwood Pharmaceuticals, Inc., a Delaware corporation (“Ironwood”) and Astellas Pharma Inc., a corporation organized under the laws of Japan (“Astellas”). Ironwood and Astellas may be referred to in this Agreement individually as a “Party” and collectively as the “Parties.”

Standard Contracts

LICENSE AGREEMENT by and between IRONWOOD PHARMACEUTICALS, INC. and LABORATORIOS ALMIRALL, S.A. April 30, 2009
License Agreement • February 2nd, 2010 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS LICENSE AGREEMENT (the “Agreement”) is entered into on this 30th day of April, 2009 (the “Effective Date”), by and among Ironwood Pharmaceuticals, Inc., a Delaware corporation (“Ironwood”) and Laboratorios Almirall, S.A., a corporation organized under the laws of Spain (“Partner”). Ironwood and Partner may be referred to in this Agreement individually as a “Party” and collectively as the “Parties.”

COLLABORATION AGREEMENT
Collaboration Agreement • February 2nd, 2010 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • New York

Type of Securities: 2,083,334 shares of the Company’s common stock, at $12.00 per share, as may be adjusted pursuant to Section 5.2.2 of the Collaboration Agreement dated September 12, 2007, by and between the Company and the Purchaser, the “Collaboration Agreement”).