0001047469-10-009914 Sample Contracts

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Letter Agreement • November 19th, 2010 • Helicos Biosciences Corp • Pharmaceutical preparations • Massachusetts

This letter agreement (this "Agreement") sets forth the arrangements between Helicos BioSciences Corporation (the "Company") and you in connection with your continued employment with the Company as it considers alternatives to its existing long-term strategic focus, including a repositioning of the Company in the genetic analysis markets. We would like to retain your focused and committed efforts during this period of uncertainty in exchange for the benefits and incentives detailed in this Agreement in addition to other compensation you may earn from your service to the Company.

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September 8, 2010
Helicos Biosciences Corp • November 19th, 2010 • Pharmaceutical preparations • Massachusetts
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