0001047469-11-002858 Sample Contracts

FOURTH AMENDMENT TO LEASE
Fourth • March 30th, 2011 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS FOURTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 3rd day of February, 2011 (the “Execution Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Microbia, Inc.) (“Tenant”).

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THIRD AMENDMENT TO LEASE
Lease • March 30th, 2011 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS THIRD AMENDMENT TO LEASE (this “Amendment”) is dated and effective as of July 1, 2010 (the “Effective Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Microbia, Inc.) (“Tenant”).

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