0001047469-14-005954 Sample Contracts

LOXO ONCOLOGY, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT
Investors’ Rights Agreement • June 30th, 2014 • Loxo Oncology, Inc. • Pharmaceutical preparations • New York

This Amended and Restated Investors’ Rights Agreement (this “Agreement”) is made and entered into as of April 24, 2014 by and among Loxo Oncology, Inc., a Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor,” any Additional Purchaser that becomes a party to this Agreement in accordance with Section 7.14 hereof and any holder of a Lender Warrant that becomes a party to this Agreement in accordance with Section 7.14 hereof.

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OFFICE LEASE of Suite 520 to LOXO ONCOLOGY, INC A Delaware corporation 400 Oyster Point Boulevard South San Francisco, CA 94080
Office Lease • June 30th, 2014 • Loxo Oncology, Inc. • Pharmaceutical preparations • California
LOXO ONCOLOGY, INC. FOUNDER’S RESTRICTED STOCK PURCHASE AGREEMENT
Founder’s Restricted Stock Purchase Agreement • June 30th, 2014 • Loxo Oncology, Inc. • Pharmaceutical preparations • California

This Agreement is made and entered into as of June 28, 2013 (the “Effective Date”) by and between Loxo Oncology, Inc. (the “Company”), a Delaware corporation, and Joshua H. Bilenker (the “Purchaser”).

DRUG DISCOVERY COLLABORATION AGREEMENT
Drug Discovery Collaboration Agreement • June 30th, 2014 • Loxo Oncology, Inc. • Pharmaceutical preparations • New York

This DRUG DISCOVERY COLLABORATION AGREEMENT (the “Agreement”), effective as of July 3, 2013 (the “Effective Date”), is made by and between Array BioPharma Inc., a Delaware corporation, having a principal place of business at 3200 Walnut Street, Boulder, Colorado 80301 (“Array”), and Loxo Oncology, Inc., a Delaware corporation, having an address at c/o Aisling Capital, 888 7th Avenue, 30th Floor, New York, New York 10106 (“Loxo”).

Sub-Lease Agreement
Sub-Lease Agreement • June 30th, 2014 • Loxo Oncology, Inc. • Pharmaceutical preparations • New York

This Sub-Lease made this 22nd day of November, 2013, by and between Tyr Energy, Inc., having an office at 7500 College Boulevard, Suite 400, Overland Park, Kansas 66210 (hereinafter referred to as “Sub-Lessor”) and Loxo Oncology, Inc., having an address of 1 Landmark Square, Stamford, Connecticut 06901 (hereinafter referred to as “Sub - Lessee”).

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