0001047469-14-007454 Sample Contracts

UNDERWRITING AGREEMENT between AASTROM BIOSCIENCES, INC. and LADENBURG THALMANN & CO. INC. as Representative of the Several Underwriters
Underwriting Agreement • September 8th, 2014 • Aastrom Biosciences Inc • Biological products, (no disgnostic substances) • New York

The undersigned, Aastrom Biosciences, Inc., a corporation formed under the laws of the State of Michigan (collectively with its subsidiaries and affiliates, including, without limitation, all entities disclosed or described in the Registration Statement (as hereinafter defined) as being subsidiaries or affiliates of Aastrom Biosciences, Inc., the “Company”), hereby confirms its agreement (this “Agreement”) with Ladenburg Thalmann & Co. Inc. (hereinafter referred to as “you” (including its correlatives) or the “Representative”) and with the other underwriters named on Schedule 1 hereto for which the Representative is acting as representative (the Representative and such other underwriters being collectively called the “Underwriters” or, individually, an “Underwriter”) as follows:

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