0001047469-14-008146 Sample Contracts

FORM OF AMENDED AND RESTATED INDEMNIFICATION AGREEMENT
Indemnification Agreement • October 7th, 2014 • Proteon Therapeutics Inc • Biological products, (no disgnostic substances) • Delaware

THIS AMENDED AND RESTATED INDEMNIFICATION AGREEMENT (the “Agreement”) is made and entered into as of , 2014 between PROTEON THERAPEUTICS, INC., a Delaware corporation (the “Company”), and (“Indemnitee”).

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UNDERWRITING AGREEMENT [Number of Firm Shares] Shares Proteon Therapeutics, Inc. Common Stock UNDERWRITING AGREEMENT
Underwriting Agreement • October 7th, 2014 • Proteon Therapeutics Inc • Biological products, (no disgnostic substances) • New York

Proteon Therapeutics, Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several underwriters named in Schedule I hereto (the “Underwriters”) for whom you are acting as representatives (the “Representatives”), an aggregate of [·] shares (the “Firm Shares”) of the common stock, par value $0.001 per share, of the Company (“Common Stock”). The Company also proposes to sell to the several Underwriters, for the sole purpose of covering over-allotments in connection with the sale of the Firm Shares, at the option of the Underwriters, up to an additional [·] shares of Common Stock (the “Option Shares”). The Firm Shares and the Option Shares are hereinafter referred to collectively as the “Shares”.

Proteon Therapeutics, Inc. Waltham, MA 02451 October 1, 2014
Letter Agreement • October 7th, 2014 • Proteon Therapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

Reference is hereby made to that certain Employment Letter Agreement (the “Original Employment Agreement”), dated as of September 9, 2013, between you and Proteon Therapeutics, Inc. (the “Company” or “Proteon”). This letter agreement (the “Agreement”) amends and restates the Original Employment Agreement in its entirety. This letter contains the basic terms of your employment with the Company. If you agree to the terms and conditions set forth in this offer letter, please sign at the end of this letter in the space indicated. This Agreement shall be effective contingent upon, and from and after, the consummation of the Company’s initial public offering (the “IPO”) of its common stock, par value $0.001 per share (“Common Stock”).

Proteon Therapeutics, Inc. Waltham, MA 02451 October 1, 2014
Proteon Therapeutics Inc • October 7th, 2014 • Biological products, (no disgnostic substances) • Massachusetts

Reference is hereby made to that certain employment letter agreement, dated as of July 19, 2007, between you and Proteon Therapeutics, Inc. (the “Company” or “Proteon”) and that certain severance agreement, dated as of September 23, 2013, between you and the Company (the “Original Employment Agreements”). This letter agreement (the “Agreement”) amends and restates the Original Employment Agreements, as amended, in their entirety. This letter contains the basic terms of your employment with the Company. If you agree to the terms and conditions set forth in this offer letter, please sign at the end of this letter in the space indicated. This Agreement shall be effective contingent upon, and from and after, the consummation of the Company’s initial public offering (the “IPO”) of its common stock, par value $0.001 per share (“Common Stock”).

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