0001047469-14-008738 Sample Contracts

NeuroDerm Ltd. [Number of Shares] Ordinary Shares (Par Value NIS 0.01 Per Share) UNDERWRITING AGREEMENT
Underwriting Agreement • November 3rd, 2014 • NeuroDerm Ltd. • Pharmaceutical preparations • New York

Introductory. NeuroDerm Ltd., a company organized under the laws of the State of Israel (the “Company”), proposes to issue and sell to the several underwriters named in Schedule A (the “Underwriters”) an aggregate of [·] ordinary shares, par value NIS 0.01 per share (the “Ordinary Shares”). The [·] Ordinary Shares to be sold by the Company are called the “Firm Shares.” In addition, the Company has granted to the Underwriters an option to purchase up to an additional [·] Ordinary Shares as provided in Section 2. The additional [·] Ordinary Shares to be sold pursuant to such option are called the “Optional Shares.” The Firm Shares and, if and to the extent such option is exercised, the Optional Shares are collectively called the “Offered Shares.” Jefferies LLC (“Jefferies”) has agreed to act as representative of the several Underwriters (in such capacity, the “Representative”) in connection with the offering and sale of the Offered Shares. To the extent there are no additional underwrite

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INDEMNIFICATION AGREEMENT
Indemnification Agreement • November 3rd, 2014 • NeuroDerm Ltd. • Pharmaceutical preparations

THIS INDEMNIFICATION AGREEMENT (the “Agreement”), dated as of , 2014, is entered into by and between NeuroDerm Ltd., an Israeli company whose address is Ruhrberg Science Building, 3 Pekeris St., Rehovot 7670212, Israel (the “Company”), and the undersigned Director or Officer of the Company whose name appears on the signature page hereto (the “Indemnitee”).

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT
Investors’ Rights Agreement • November 3rd, 2014 • NeuroDerm Ltd. • Pharmaceutical preparations

THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (“Agreement”) is made as of the 14th day of August, 2014, by and among NeuroDerm Ltd., an Israeli corporation with registration number 51-339457-7 (the “Company”) ,the investors and/or lenders listed under the attached Schedule A (each an “Investor” and collectively the “Investors”), and each of the shareholders of the Company and/or the holders of any securities convertible into shares of the Company (with the exception only of holders of options granted under the Company’s employee share option plan), listed on Schedule B hereto, each of whom is referred to herein as a “Shareholder”.

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