0001047469-15-000916 Sample Contracts

HEALTHCARE PROVIDER CONSULTING AGREEMENT Ironwood Contract #HIP-541
Healthcare Provider Consulting Agreement • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • Massachusetts

THIS HEALTHCARE PROVIDER CONSULTING AGREEMENT (together with its Business Terms Exhibit, the “Agreement”) made as of December 16, 2014 (the “Effective Date”) is between Ironwood Pharmaceuticals, Inc., a Delaware corporation having an address at 301 Binney Street, Cambridge, MA 02142 (“Ironwood”), Christopher Walsh, PhD and having an address at 241 Perkins Street, Unit B 601, Boston, MA 02130 (“Consultant”). Ironwood desires to have the benefit of Consultant’s knowledge and experience, and Consultant desires to provide Consulting Services (defined below) to Ironwood, all as provided in this Agreement.

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RESTRICTED STOCK AGREEMENT IRONWOOD PHARMACEUTICALS, INC.
Restricted Stock Agreement • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

AGREEMENT made as of the [·] day of [·] (the “Grant Date”), between Ironwood Pharmaceuticals, Inc. (the “Company”), a Delaware corporation, and [·] (the “Participant”).

TENTH AMENDMENT TO LEASE
Lease • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS TENTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 21st day of January, 2015 (the “Execution Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (“Tenant,” formerly known as Microbia, Inc.).

SUBLEASE
Sublease • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

This SUBLEASE is made as of July 1, 2014, by and between Ironwood Pharmaceuticals, Inc., a Delaware corporation having an address at 301 Binney Street, Cambridge, Massachusetts (“Sublessor”) and Biogen Idec MA Inc., a Massachusetts corporation having an address at 225 Binney Street, Cambridge MA 02142 (“Sublessee”).

NINTH AMENDMENT TO LEASE
Lease • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS NINTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 27th day of October, 2014, by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (“Tenant,” formerly known as Microbia, Inc.).

EIGHTH AMENDMENT TO LEASE
Lease • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS EIGHTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 8th day of July, 2014 (the “Execution Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Microbia, Inc.) (“Tenant”).

IRONWOOD PHARMACEUTICALS, INC. EXECUTIVE SEVERANCE AGREEMENT
Executive Severance Agreement • February 18th, 2015 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • Massachusetts

This Severance Agreement (this “Agreement”) is made as of the day of , (the “Effective Date”) by and between Ironwood Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and (the “Executive”).

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