0001047469-15-007251 Sample Contracts

MIRNA THERAPEUTICS, INC. INDEMNIFICATION AGREEMENT
Indemnification Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Delaware

This Indemnification Agreement (this “Agreement”) is effective as of [·] by and between Mirna Therapeutics, Inc., a Delaware corporation (the “Company”), and «Indemnitee» (“Indemnitee”).

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AMENDMENT No. 1 to LICENSE AGREEMENT
License Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations

This AMENDMENT NO. 1 to LICENSE AGREEMENT (this “Amendment”) is made and entered into effective as of December 27, 2013 (the “Amendment Effective Date”), by and between Mirna Therapeutics, Inc., a Delaware corporation with offices at 2150 Woodward Street, Suite 100, Austin, Texas 78744 (“MirnaRx”), and Marina Biotech, Inc., a Delaware corporation with offices at 3830 Monte Villa Parkway, Bothell, Washington 98021 (“Marina Bio”).

LICENSE AGREEMENT
License Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • New York

THIS LICENSE AGREEMENT (the “Agreement”) is made and entered into effective as of December 22, 2011 (the “Effective Date”) by and between MIRNA THERAPEUTICS, INC., a Delaware corporation with a place of business at 2150 Woodward Street, Suite 100, Austin, Texas 78744 (“MirnaRx”), and MARINA BIOTECH, INC., a Delaware corporation with a place of business at 3830 Monte Villa Parkway, Bothell, Washington 98021 USA (“Marina Bio”). Marina Bio and MirnaRx are sometimes referred to herein individually as a “Party”, and collectively as the “Parties.”

AMENDED AND RESTATED AGREEMENT
Amended and Restated Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations

THIS AMENDED AND RESTATED AGREEMENT (the “Agreement”) by and between YALE UNIVERSITY, a corporation organized and existing under and by virtue of a charter granted by the general assembly of the Colony and State of Connecticut and located in New Haven, Connecticut (“YALE”), and Mirna Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware and with principal offices located in Austin, Texas (“LICENSEE”) is effective as of the date of final signature below (“EFFECTIVE DATE”).

MIRNA THERAPEUTICS, INC. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • California

THIS THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this “Agreement”) is entered into as of this 31st day of March, 2015, by and among MIRNA THERAPEUTICS, INC., a Delaware corporation (the “Company”), and each of the persons and entities listed on Exhibit A hereto (the “Investors” and each individually an “Investor”).

Contract
License Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Delaware

This Agreement is made in connection with the Stock Purchase Agreement dated as of September 1, 2015 between the Company and CPRIT (the “Purchase Agreement”), pursuant to which CPRIT has agreed to purchase shares of the Company’s Common Stock (the “Shares” and such offering, the “Offering”). The execution and delivery of this Agreement is a condition precedent to certain obligations of CPRIT under the Purchase Agreement.

AMENDMENT No. 2 to LICENSE AGREEMENT
License Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations

This AMENDMENT NO. 2 to LICENSE AGREEMENT (this “Amendment No. 2”) is made and entered into effective as of May 11, 2015 (the “Amendment No. 2 Effective Date”), by and between Mirna Therapeutics, Inc., a Delaware corporation with offices at 2150 Woodward Street, Suite 100, Austin, Texas 78744 (“MirnaRx”), and Marina Biotech, Inc., a Delaware corporation with offices c/o Pryor Cashman LLP, 7 Times Square, New York, New York 10036 (“Marina Bio”).

Contract
Employment Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Texas

This EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into this 22 day of May, 2013 (the “Effective Date”) by and between Mirna Therapeutics, Inc., a Delaware corporation (the “Company”) and Sinil Kim, M.D. (“Employee”).

MIRNA THERAPEUTICS, INC. CHANGE IN CONTROL SEVERANCE AGREEMENT
Change in Control Severance Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Texas

This Change in Control Severance Agreement (the “Agreement”) is made and entered into by and between [ ] (“Executive”) and Mirna Therapeutics, Inc. (the “Company”), effective as of the latest date set forth by the signatures of the parties hereto below (the “Effective Date”).

RECITALS
State of Texas • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Texas

performed or services delivered and comply with all federal and state laws regarding the conduct of the research or service.

MIRNA THERAPEUTICS LETTERHEAD]
Mirna Therapeutics, Inc. • September 11th, 2015 • Pharmaceutical preparations

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

MIRNA THERAPEUTICS LETTERHEAD]
Employment Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Texas

This EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into this 1st day of March, 2014 (the “Effective Date”) by and between Mirna Therapeutics, Inc., a Delaware corporation (the “Company”) and Casi DeYoung (“Employee”).

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations

This FIRST AMENDMENT TO EMPLOYMENT AGREEMENT (the “Amendment”) is effective as of January 5, 2011 (the “Effective Date”) and made by and between Mirna Therapeutics, Inc., a Delaware corporation (the “Company”) and Paul Lammers, MD, MSc (“Employee”).

MIRNA THERAPEUTICS LETTERHEAD]
Employment Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Texas

This EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into this 4th day of November, 2009 (the “Effective Date”) by and between Mima Therapeutics Inc., a Delaware corporation (the “Company”), and Paul Lammers, MD, MSc (“Employee”).

STOCK PURCHASE AGREEMENT
Stock Purchase Agreement • September 11th, 2015 • Mirna Therapeutics, Inc. • Pharmaceutical preparations • Texas

This Stock Purchase Agreement (this “Agreement”) is dated as of September 1, 2015 (the “Effective Date”) by and between Mirna Therapeutics, Inc., a Delaware corporation (the “Company”), and the Cancer Prevention and Research Institute of Texas, an institution of the State of Texas (“CPRIT”).

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