0001047469-17-002262 Sample Contracts

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FIRST AMENDMENT TO LEASE
Lease • March 31st, 2017 • Leap Therapeutics, Inc. • Pharmaceutical preparations

This First Amendment to Lease (this “Amendment”) is made as of January 4, 2016 by and between Bulfinch Square Limited Partnership, a Massachusetts limited partnership (“Landlord”), and Healthcare Ventures LLC, a Delaware limited liability company (“Tenant”).

CONSENT TO ASSIGNMENT AND ASSUMPTION OF LEASE
Assignment and Assumption Agreement • March 31st, 2017 • Leap Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

This Consent to Assignment and Assumption of Lease (this “Agreement”) is made as of the 19th day of December, 2016 by and among Bulfinch Square Limited Partnership, a Massachusetts limited partnership (“Landlord”), HealthCare Ventures LLC, a Delaware limited liability company (“Tenant”) and Leap Therapeutics, Inc., a Delaware corporation (“Assignee”).

AMENDMENT TO LEASE
Lease • March 31st, 2017 • Leap Therapeutics, Inc. • Pharmaceutical preparations

This Amendment to Lease (this “Amendment”) is made as of June 30, 2015 by and between BULFINCH SQUARE LIMITED PARTNERSHIP, a Massachusetts limited partnership (“Landlord”) and Healthcare Ventures, LLC a Delaware limited liability company “Tenant”).

AMENDMENT NO. 2 TO WARRANT
Leap Merger Agreement • March 31st, 2017 • Leap Therapeutics, Inc. • Pharmaceutical preparations

THIS AMENDMENT NO. 2, dated as of January 23, 2017 (the “Amendment”), to that certain Warrant to Purchase Preferred A Shares of Macrocure Ltd., an Israeli company (the “Company”), dated May 3, 2012, as amended by Amendment No. 1 thereto, dated as of July 22, 2013 (as so amended, the “Warrant”), is entered into by and among the Company, the individual or entity listed on the signature page hereto, who/which is the holder of the Warrant (the “Holder”), and Leap Therapeutics, Inc., a company organized under the laws of the State of Delaware (the “Acquirer”). Capitalized terms used herein and not otherwise defined shall have the meaning ascribed to them in the Warrant.

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