0001047469-18-004009 Sample Contracts

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT
Investors’ Rights Agreement • May 23rd, 2018 • Aptinyx Inc. • Pharmaceutical preparations • Delaware

THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (this “Agreement”), is made as of the 11th day of December, 2017, by and among Aptinyx Inc., a Delaware corporation (the “Company”) and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor.”

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OFFICE LEASE AGREEMENT Between FSP 909 DAVIS STREET LLC, a Delaware limited liability company as Landlord and APTINYX INC., a Delaware corporation as Tenant Premises: Suite 600 Evanston, Illinois 60201
Office Lease Agreement • May 23rd, 2018 • Aptinyx Inc. • Pharmaceutical preparations • Illinois

Tenant’s Address: 909 Davis Street Evanston, Illinois 60201 Attn: Patricia Adams, Vice President of Human Resources and Administration

RESEARCH COLLABORATION AGREEMENT BY AND BETWEEN NAUREX INC. AND APTINYX INC. DATED AS OF JULY 24, 2015
Research Collaboration Agreement • May 23rd, 2018 • Aptinyx Inc. • Pharmaceutical preparations • New York

This Research Collaboration Agreement (this “Agreement”), dated as of July 24, 2015 (the “Execution Date”), is entered into by and between Naurex Inc., a Delaware corporation (the “Company”) and Aptinyx Inc., a Delaware corporation (“SpinCo”). The Company and SpinCo are each referred to herein by name or as a “Party” or, collectively, as “Parties”.

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