0001047469-18-004374 Sample Contracts

UNDERWRITING AGREEMENT APTINYX INC.
Underwriting Agreement • June 11th, 2018 • Aptinyx Inc. • Pharmaceutical preparations • New York
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APTINYX INC. [FORM OF] DIRECTOR INDEMNIFICATION AGREEMENT
Director Indemnification Agreement • June 11th, 2018 • Aptinyx Inc. • Pharmaceutical preparations • Delaware

This INDEMNIFICATION AGREEMENT (“Agreement”) is made as of [ ] by and between Aptinyx Inc., a Delaware corporation (the “Company”), and [Director] (“Indemnitee”).

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • June 11th, 2018 • Aptinyx Inc. • Pharmaceutical preparations • Illinois

This Amended and Restated Employment Agreement (the “Agreement”) is made by and between Aptinyx Inc. (the “Company”) and (the “Executive”). Except with respect to the Restrictive Covenants Agreement and the Equity Documents (each as defined below), this Agreement supersedes, amends and restates in all respects all prior agreements and understandings between the Executive and the Company regarding the subject matter herein, including without limitation that certain employment agreement dated [DATE] (the “Prior Agreement”). This Agreement shall be effective as of the closing of the Company’s first underwritten public offering of its equity securities pursuant to an effective registration statement under the Securities Act of 1933, as amended (the “Effective Date”).

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