0001047469-19-003982 Sample Contracts

Investigator-Initiated Clinical Trial Agreement
Investigator-Initiated • July 3rd, 2019 • Annovis Bio, Inc. • Pharmaceutical preparations • California

This Clinical Trial Agreement (“Agreement”) is made and entered into effective as of the full execution hereof (“Effective Date”), by and between The Regents of the University of California, a California constitutional corporation, on behalf of its San Diego campus, located at 9500 Gilman Drive, La Jolla, CA 92093, California (“Institution”), and QR Pharma, Inc., a Delaware corporation having its principal place of business at 1055 Westlakes Drive, Suite 300, Berwyn PA 19312 (“Company”), (each may be individually referred to as a “Party” and collectively, as “the Parties”).

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License Agreement Amendment
License Agreement • July 3rd, 2019 • Annovis Bio, Inc. • Pharmaceutical preparations • District of Columbia

This license agreement amendment (“Amendment’’) amends the License Agreement dated November 10, 2008 (“Agreement”) by and between RAPTOR THERAPEUTICS INC., having its principal place of business at 9 Commercial Blvd., Suite 200, Novato, CA 94949 (hereinafter referred to as “Licensor’’), formerly known as TorreyPines Therapeutics, Inc.; and QR PHARMA, INC., having its principal place of business at 1223 Foxglove Lane, West Chester, PA 19380 (hereinafter referred to as “Licensee”).

License Agreement Amendment Number 2
License Agreement Amendment Number • July 3rd, 2019 • Annovis Bio, Inc. • Pharmaceutical preparations

This license agreement amendment number 2 (“Amendment Number 2”), effective as of May 2, 2012 (“Effective Date”), amends the License Agreement dated November 10, 2008, as amended November 18, 2011 (collectively, the “Current Agreement”) by and between RAPTOR THERAPEUTICS INC., having its principal place of business at 9 Commercial Blvd., Suite 200, Novato, CA 94949 (hereinafter referred to as “Licensor”), formerly known as TorreyPines Therapeutics, Inc.; and QR PHARMA, INC., having its principal place of business at 1055 Westlakes Drive, Suite 300, Berwyn, PA 19312 (hereinafter referred to as “Licensee”)..

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • July 3rd, 2019 • Annovis Bio, Inc. • Pharmaceutical preparations • Pennsylvania

EMPLOYMENT AGREEMENT effective as of May 10, 2019 between Annovis Bio, Inc. (the “Employer”), a Delaware corporation, and Maria L. Maccecchini (the “Employee”).

LICENSE AGREEMENT
License Agreement • July 3rd, 2019 • Annovis Bio, Inc. • Pharmaceutical preparations • New York

THIS LICENSE AGREEMENT (this “Agreement”), dated as of November 10, 2008, is by and between TORREYPINES THERAPEUTICS, INC., a Delaware corporation having its principal place of business at 11085 North Torrey Pines Road, Suite 300, La Jolla, CA 92037 (hereinafter referred to as “Licensor”); and QR Pharma, Inc., a Delaware corporation and having its principal place of business at 1223 Foxglove Lane, West Chester, PA 19380 (hereinafter referred to as “Licensee”). Licensor and Licensee are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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