0001059790-07-000036 Sample Contracts

FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • November 5th, 2007 • Pozen Inc /Nc • Pharmaceutical preparations

This FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (the “First Amendment”), is entered into as of September 28, 2007, by and between POZEN Inc. (the “Company”) and Marshall E. Reese, Ph.D. (“Executive”).

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FIRST AMENDMENT TO RESTRICTED STOCK UNIT AGREEMENT
Restricted Stock Unit Agreement • November 5th, 2007 • Pozen Inc /Nc • Pharmaceutical preparations • Delaware

This FIRST AMENDMENT TO RESTRICTED STOCK UNIT AGREEMENT (the “First Amendment”), is entered into effective September 28, 2007, by and between POZEN Inc. (“POZEN” or the “Company”), and John R. Plachetka (the “Grantee”).

AMENDMENT NO. 1 TO THE COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 5th, 2007 • Pozen Inc /Nc • Pharmaceutical preparations

This Amendment No. 1 to the Collaboration and License Agreement (this “Amendment”) is made effective as of September 6, 2007 (the “Amendment Effective Date”) by and between POZEN INC., a Delaware corporation having offices at 1414 Raleigh Road, Suite 400, Chapel Hill, North Carolina (“POZEN”), and ASTRAZENECA AB, a Swedish corporation having an office at SE-431 83, Mölndal, Sweden (“AstraZeneca”). POZEN and AstraZeneca may be referred to herein individually as a “Party,” or collectively as the “Parties.”

Contract
Incentive Cash Award Agreement • November 5th, 2007 • Pozen Inc /Nc • Pharmaceutical preparations • Delaware
FIRST AMENDMENT TO SECOND AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • November 5th, 2007 • Pozen Inc /Nc • Pharmaceutical preparations • North Carolina

This FIRST AMENDMENT TO SECOND AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (the “First Amendment”), is entered into as of September 28, 2007 (the “Effective Date”), by and between POZEN Inc. (the “Company”) and John R. Plachetka (“Executive”).

FIRST AMENDMENT TO RESTRICTED STOCK UNIT AGREEMENT
Restricted Stock Unit Agreement • November 5th, 2007 • Pozen Inc /Nc • Pharmaceutical preparations • Delaware

This FIRST AMENDMENT TO RESTRICTED STOCK UNIT AGREEMENT (the “First Amendment”), is entered into as of September 28, 2007, by and between POZEN Inc. (“POZEN”) and John R. Plachetka (the “Grantee”).

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