0001062822-10-000037 Sample Contracts

AMENDED AND RESTATED PURCHASE OPTION AGREEMENT
Purchase Option Agreement • August 2nd, 2010 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

This AMENDED AND RESTATED PURCHASE OPTION AGREEMENT (this “Agreement”) is entered into as of July 30, 2010 (the “Closing Date”), by and among LEXICON PHARMACEUTICALS, INC., a Delaware corporation (“Lexicon”), SYMPHONY ICON HOLDINGS LLC, a Delaware limited liability company (“Holdings”), and SYMPHONY ICON, INC., a Delaware corporation (“Symphony Icon”). Capitalized terms used herein and not defined herein shall have the meanings assigned to such terms in Annex A attached hereto.

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AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT between LEXICON PHARMACEUTICALS, INC. and SYMPHONY ICON HOLDINGS LLC Dated as of July 30, 2010
Registration Rights Agreement • August 2nd, 2010 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of July 30, 2010, by and between LEXICON PHARMACEUTICALS, INC., a Delaware corporation (“Lexicon”), and SYMPHONY ICON HOLDINGS LLC, a Delaware limited liability company (together with its permitted successors, assigns and transferees, “Holdings”).

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