LEXICON GENETICS LETTERHEAD] February 19, 2003Lexicon Pharmaceuticals, Inc./De • November 8th, 2010 • Pharmaceutical preparations • Texas
Company FiledNovember 8th, 2010 Industry JurisdictionWe are pleased to invite you to become the Chairman of the Medical Advisory Board of, and a special consultant to, Lexicon Genetics Incorporated (which, together with its subsidiaries and affiliates, is referred to as the “Company” or “Lexicon”). The purpose of this letter agreement (this “Agreement”) is to set forth our mutual understanding of the terms and conditions under which you would provide consulting services in those capacities, as set forth below.