0001062822-11-000021 Sample Contracts

AMENDMENT NO. 1 TO CONSULTING AGREEMENT
Consulting Agreement • March 16th, 2011 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Texas

This Amendment No. 1 to Consulting Agreement (this “Amendment”) is made and entered into effective as of November 22, 2010 (the “Amendment Effective Date”) by and between Lexicon Pharmaceuticals, Inc., a corporation having a place of business at 8800 Technology Forest Place, The Woodlands, Texas 77381 (“Lexicon”), and Philip M. Brown, M.D., J.D., an individual (“Consultant”). This Amendment amends that certain Consulting Agreement dated October 16, 2010 (the “Original Agreement”) between Lexicon and Consultant. Capitalized terms used without definition in this Amendment shall have the meanings given to such terms in the Original Agreement.

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