0001062822-16-000075 Sample Contracts

AMENDMENT NO. 1 TO AMENDED AND RESTATED PURCHASE OPTION AGREEMENT
Purchase Option Agreement • October 5th, 2016 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations

This Amendment No. 1 to Amended and Restated Purchase Option Agreement (this “Amendment”) is made and entered into effective as of September 30, 2016 (the “Amendment Effective Date”) by and between Lexicon Pharmaceuticals, Inc., a Delaware corporation (“Lexicon”), Symphony Icon Holdings LLC, a Delaware limited liability company (“Holdings”), and Symphony Icon, Inc., a Delaware corporation (“Symphony Icon”). This Amendment amends that certain Amended and Restated Purchase Option Agreement, dated July 30, 2010 (the “Original Agreement”), between Lexicon, Holdings and Symphony Icon. Capitalized terms used without definition in this Amendment shall have the meanings given to such terms in the Original Agreement.

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