0001062822-16-000081 Sample Contracts

SECOND AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 7th, 2016 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations

This Second Amendment to Collaboration and License Agreement (the “Amendment”) is entered into effective as of the last date set forth on the signature page hereof (the “Effective Date”) by and between Lexicon Pharmaceuticals, Inc. (formerly known as Lexicon Genetics Incorporated), a Delaware corporation (“Lexicon”) and Bristol-Myers Squibb Company, a Delaware corporation (“BMS”).

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