0001062822-17-000054 Sample Contracts

AMENDMENT NO. 1 TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 8th, 2017 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations

This Amendment No. 1 to Collaboration and License Agreement (this “Amendment”), is dated as of July 1st, 2017 (the “Amendment Effective Date”) and is entered into by and between Lexicon Pharmaceuticals, Inc., a Delaware corporation (“Lexicon”), and SANOFI-AVENTIS DEUTSCHLAND GmbH, a German corporation (assignee of SANOFI, a société anonyme under the laws of France), with its principal place of business at 65926 Frankfurt am Main, Germany (“Sanofi”). Lexicon and Sanofi are sometimes referred to herein individually as a “Party” and collectively as the “Parties.” Capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Agreement.

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