0001070698-13-000063 Sample Contracts

FIRST AMENDMENT TO LEASE (EXPANSION)
Lease • August 9th, 2013 • Raptor Pharmaceutical Corp • Pharmaceutical preparations

This First Amendment to Lease (the "Agreement") is entered into as of June 10, 2013, by and between HAMILTON MARIN, LLC, a California limited liability company ("Landlord"), and RAPTOR PHARMACEUTICAL CORP., a Delaware corporation ("Tenant"), with respect to the following facts and circumstances:

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Second Amendment to Manufacturing Services Agreement between Patheon Pharmaceuticals Inc., and Raptor Pharmaceuticals Inc.
Manufacturing Services Agreement • August 9th, 2013 • Raptor Pharmaceutical Corp • Pharmaceutical preparations

Background: Patheon Pharmaceuticals Inc., ("Patheon") and Raptor Pharmaceuticals Inc., (formerly known as Raptor Therapeutics, Inc.), ("Raptor") entered into a Manufacturing Services Agreement dated November 15, 2010, as amended on April 5, 2012 (the "Agreement"). Patheon and Raptor wish to further amend the Agreement to add Raptor Pharmaceuticals Europe B.V., a wholly owned subsidiary of RPTP European Holdings C.V. (a wholly-owned subsidiary of Raptor) as an additional party to the Agreement and to update the Pricing in Schedule B.

OFFICE LEASE HAMILTON LANDING NOVATO, CALIFORNIA 94949
Office Lease • August 9th, 2013 • Raptor Pharmaceutical Corp • Pharmaceutical preparations • California

This Office Lease, which includes the preceding Summary of Basic Lease Information (the "Summary") attached hereto and incorporated herein by this reference (the Office Lease and Summary to be known sometimes collectively hereafter as the "Lease"), dated as of the date set forth in Article 1 of the Summary, is made by and between HAMILTON MARIN, LLC, a California limited liability company ("Landlord"), and RAPTOR PHARMACEUTICAL CORP., a Delaware corporation ("Tenant").

PHARMACY SERVICES AGREEMENT
Pharmacy Services Agreement • August 9th, 2013 • Raptor Pharmaceutical Corp • Pharmaceutical preparations • Delaware

THIS PHARMACY SERVICES AGREEMENT (as amended, supplemented or otherwise modified from time to time, this "Agreement") is made this 3rd day of April, 2013, (the "Effective Date") by and between Accredo Health Group, Inc., a Delaware corporation having offices at 1640 Century Center Parkway, Memphis, TN 38134 ("Accredo"), and Raptor Pharmaceuticals Inc., a Delaware corporation having offices at 9 Commercial Boulevard, Suite 200, Novato, CA 94949 ("Company"). Accredo and Company are referred to herein individually as a "Party" and collectively as the "Parties." The Parties hereto agree as follows:

WHOLESALE PRODUCT PURCHASE AGREEMENT
Wholesale Product Purchase Agreement • August 9th, 2013 • Raptor Pharmaceutical Corp • Pharmaceutical preparations • Delaware

THIS WHOLESALE PRODUCT PURCHASE AGREEMENT (as amended, supplemented or otherwise modified from time to time, this "Agreement") is made this 3rd day of April, 2013, (the "Effective Date") by and between Accredo Health Group, Inc., a Delaware corporation having offices at 1640 Century Center Parkway, Memphis, TN 38134 ("Distributor"), and Raptor Pharmaceuticals Inc., a Delaware corporation having offices at 9 Commercial Boulevard, Suite 200, Novato, CA 94949 ("Company"). Distributor and Company are referred to herein individually as a "Party" and collectively as the "Parties". All Exhibits attached hereto are incorporated herein to the Agreement. The Parties hereto agree as follows:

Amendment to Manufacturing Services Agreement between Patheon Pharmaceuticals Inc., and Raptor Therapeutics, Inc.
Manufacturing Services Agreement • August 9th, 2013 • Raptor Pharmaceutical Corp • Pharmaceutical preparations

Background: Patheon Pharmaceuticals Inc., ("Patheon") and Raptor Therapeutics, Inc., ("Raptor") entered into a Manufacturing Services Agreement dated November 15, 2010 (the "Agreement"). Patheon and Raptor wish to amend the Agreement to revise Schedule B.

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