0001091818-06-000115 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • March 14th, 2006 • Human Biosystems Inc • Services-commercial physical & biological research • California

Registration Rights Agreement dated as of March 7, 2006 (this “Agreement”) by and between Human BioSystems, a California corporation, with principal executive offices located at 1127 Harker Avenue, Palo Alto, California 94301 (the “Company”), and La Jolla Cove Investors, Inc. (the “Holder”).

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Contract
Convertible Debenture Agreement • March 14th, 2006 • Human Biosystems Inc • Services-commercial physical & biological research • California

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE, AND IS BEING OFFERED AND SOLD PURSUANT TO AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND SUCH LAWS. THIS SECURITY MAY NOT BE SOLD OR TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT OR SUCH OTHER LAWS.

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • March 14th, 2006 • Human Biosystems Inc • Services-commercial physical & biological research • California

Securities Purchase Agreement dated as of March 7, 2006 (this “Agreement”) by and between Human BioSystems, a California corporation, with principal executive offices located at 1127 Harker Avenue, Palo Alto, California 94301 (the “Company”), and La Jolla Cove Investors, Inc. (“Holder”).

WARRANT TO PURCHASE COMMON STOCK
Warrant to Purchase Common Stock • March 14th, 2006 • Human Biosystems Inc • Services-commercial physical & biological research • California

THIS WARRANT TO PURCHASE COMMON STOCK is being issued pursuant to that certain Securities Purchase Agreement dated as of the date hereof (the “Purchase Agreement”) between Human BioSystems, a California corporation (the “Company”) and La Jolla Cove Investors, Inc. (“Holder”).

ADDENDUM TO CONVERTIBLE DEBENTURE, WARRANT TO PURCHASE COMMON STOCK AND SECURITIES PURCHASE AGREEMENT
Convertible Debenture, Warrant to Purchase Common Stock and Securities Purchase Agreement • March 14th, 2006 • Human Biosystems Inc • Services-commercial physical & biological research

This Addendum to Convertible Debenture, Warrant to Purchase Common Stock and Securities Purchase Agreement (“Addendum”) is entered into as of the 7th day of March 2006 by and between Human BioSystems, Inc., Inc., a California corporation (“Human”), and La Jolla Cove Investors, Inc., a California corporation (“LJCI”).

ADDENDUM TO CONVERTIBLE DEBENTURE
Convertible Debenture Addendum • March 14th, 2006 • Human Biosystems Inc • Services-commercial physical & biological research

This Addendum to Convertible Debenture and Warrant to Purchase Common Stock (“Addendum”) is entered into as of the 7th day of March 2006 by and between Human BioSystems, Inc., a California corporation (“Human”), and La Jolla Cove Investors, Inc., a California corporation (“LJCI”).

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