0001104659-02-004237 Sample Contracts

From: David Housman Date: June 1, 2002 Subject: First Amendment to Employment Offer Letter
Employment Offer Letter • August 15th, 2002 • Variagenics Inc • Services-commercial physical & biological research

We hereby agree that your Employment Offer Letter, dated September 5, 2001 and comprised of the Offer Letter, the Inventions and Non-Disclosure Agreement and the Non Compete and Non Solicitation Agreement (collectively, the “Offer Letter”), be and hereby is amended effective June 1, 2002, as provided for herein. Except as specifically modified herein, the terms of the Offer Letter, and all terms and conditions of your employment with Variagenics, Inc. (including any of its successors or assigns, the “Company”) shall remain in full force and effect. This first amendment to your Offer Letter shall be referred to herein as the “Amendment.”

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Variagenics, Inc.
Retention Agreement • August 15th, 2002 • Variagenics Inc • Services-commercial physical & biological research

This letter agreement shall amend the Amended and Restated Retention Agreement executed on or about February 13, 2002 between Variagenics, Inc. (the “Company”) and you. To the extent that this letter agreement augments or differs from the terms of your Employment Agreement dated March 18, 1999 (the “Employment Agreement”), any of your Stock Option Agreements dated September 22, 1999, February 11, 2000 or January 3, 2001 (collectively, the “Option Agreements”) or the aforementioned Amended and Restated Retention Agreement, those agreements are hereby amended to such extent. You agree that the Release executed by you today, however, shall remain in full force and effect, as stated therein.

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