0001104659-03-026682 Sample Contracts

FOURTH AMENDMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENT DATED MAY 31, 1991
Research Collaboration and License Agreement • November 14th, 2003 • Vical Inc • Biological products, (no disgnostic substances)

This Fourth Amendment (“Fourth Amendment”), entered into this 20th day of August, 2003 (“Amendment Effective Date”), between Merck & Co., Inc. (“MERCK”) and Vical Incorporated (“VICAL”), amends the Research Collaboration and License Agreement between MERCK and VICAL dated May 31, 1991, as previously amended on April 27, 1994, December 13, 1995, and November 3, 1997 (collectively the “Agreement”).

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