0001104659-04-033933 Sample Contracts

Contract
Development and Supply Agreement • November 5th, 2004 • Medicines Co /De • Pharmaceutical preparations • New York

CONFIDENTIAL MATERIAL APPEARING IN THIS DOCUMENT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION IN ACCORDANCE WITH RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1934, AS AMENDED, AND RULE 24B-2 PROMULGATED THEREUNDER. OMITTED INFORMATION HAS BEEN REPLACED WITH ASTERISKS.

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FIRST AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • November 5th, 2004 • Medicines Co /De • Pharmaceutical preparations • New Jersey

THIS FIRST AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”), made as of the 1st day of August 2004, is entered into by THE MEDICINES COMPANY, a Delaware corporation with its principal place of business at 8 Campus Drive, Parsippany, New Jersey 07054 (the “Company”), and DAVID M. STACK, residing at One Robin Drive, Oak Ridge, New Jersey 07438 (the “Employee”).

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