0001104659-04-035725 Sample Contracts

AMENDMENT NO. 1 TO SUBLEASE AGREEMENT
Sublease Agreement • November 15th, 2004 • Metabasis Therapeutics Inc • Pharmaceutical preparations

This Amendment No. 1 to Sublease Agreement (this “Amendment”) is made as of March 18, 2004 by and between SICOR INC., a Delaware corporation (“Sublandlord”) and METABASIS THERAPEUTICS, INC., a Delaware corporation (“Subtenant”).

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AMENDMENT NO. 2 TO SUBLEASE AGREEMENT
Sublease Agreement • November 15th, 2004 • Metabasis Therapeutics Inc • Pharmaceutical preparations

This Amendment No. 2 to Sublease Agreement (this “Amendment”) is made as of September 14, 2004 by and between SICOR INC., a Delaware corporation (“Sublandlord”), and METABASIS THERAPEUTICS, INC., a Delaware corporation (“Subtenant”).

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