0001104659-05-008997 Sample Contracts

FIRST AMENDMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENT
Research Collaboration and License Agreement • March 2nd, 2005 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This FIRST AMENDMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENT (this “First Amendment”) dated as of October 20, 2004, is entered into by and between Merck & Co., Inc. (“MERCK”) and ARENA PHARMACEUTICALS, INC., (“ARENA”) and amends that certain Research Collaboration and License Agreement between MERCK and ARENA, effective as of October 21, 2002 (the “Agreement”).

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COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • March 2nd, 2005 • Arena Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS COLLABORATION AND LICENSE AGREEMENT (this “Agreement”) is entered into as of December 20, 2004 (the “Effective Date”) by and between ARENA PHARMACEUTICALS, INC., a Delaware corporation having an office at 6166 Nancy Ridge Drive, San Diego, CA 92121 (“Arena”), and ORTHO-MCNEIL PHARMACEUTICAL, INC., a New Jersey corporation having an office at 1000 U.S. Route 202, Raritan, New Jersey 08869 (“J&J”). Arena and J&J may each be referred to individually as a “Party”, and collectively as the “Parties”.

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