0001104659-05-017525 Sample Contracts

AGREEMENT REGARDING JOINT FILING
Joint Filing Agreement • April 21st, 2005 • BVF Partners L P/Il • Pharmaceutical preparations

The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, Investment 10, L.L.C., an Illinois limited liability company, BVF Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by Schedule 13D, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them.

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SECURITIES PURCHASE AGREEMENT ORDINARY SHARES AND WARRANTS TO PURCHASE ORDINARY SHARES OF FLAMEL TECHNOLOGIES S.A. DATED AS OF FEBRUARY 29, 2000
Securities Purchase Agreement • April 21st, 2005 • BVF Partners L P/Il • Pharmaceutical preparations • New York

THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”), is made as of this 29th day of February, 2000, by and among FLAMEL TECHNOLOGIES S.A., a French societe anonyme (the “Company”), BIOTECHNOLOGY VALUE FUND, L.P., a Delaware limited partnership, BIOTECHNOLOGY VALUE FUND II, L.P., a Delaware limited partnership, INVESTMENT 10 L.L.C., an Illinois limited liability company (collectively, the “BVF Investors”), and ALTA BIOPHARMA PARTNERS, a Delaware limited partnership, Alta Embarcadero Biopharma, LLC, a California limited liability company, and Flamel Chase Partners (AltaBio), LLC, a Delaware limited liability company (collectively “Alta”); Chase EUROPEAN EQUITY ASSOCIATES, LLC, a Delaware limited liability company (“Chase” and, together with the BVF Investors, and Alta, the “Investors”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • April 21st, 2005 • BVF Partners L P/Il • Pharmaceutical preparations • New York

REGISTRATION RIGHTS AGREEMENT, dated as of April 5, 2000, by and among Flamel Technologies S.A., a societe anonyme organized under the laws of The Republic of France (the “Company”) and BIOTECHNOLOGY VALUE FUND, L.P., a Delaware limited partnership, BIOTECHNOLOGY VALUE FUND II, L.P., a Delaware limited partnership, INVESTMENT 10 L.L.C., an Illinois limited liability company (collectively, the “BVF Investors”), and ALTA BIOPHARMA PARTNERS, a Delaware limited partnership, ALTA EMBARCADERO BIOPHARMA, LLC, a California limited liability company, and FLAMEL CHASE PARTNERS (ALTABIO), LLC, a Delaware limited liability company (collectively, “Alta”); and CHASE EUROPEAN EQUITY ASSOCIATES, LLC, a Delaware limited liability company (“Chase” and, together with the BVF Investors and Alta, the “Investors”).

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