0001104659-05-022172 Sample Contracts

CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS.
Protein Design Labs Inc/De • May 10th, 2005 • Biological products, (no disgnostic substances)

This letter, when signed for ESP and returned to me, will amend the Sublicense and Supply Agreement of September 1, 1993, (that is under agreement for assignment by American Home Products Corporation, now Wyeth, to ESP) (the Agreement) on the first day of a calendar quarter following the assignment of the Agreement to ESP and the fulfillment of all the conditions for license assignment enumerated in the letter agreement of April 18, 2002, among Wyeth, ESP and Roche (formerly Syntex (U.S.A.) LLC), provided that there be no disputes about payments due Roche and also provided that the Quality Agreement and side letter regarding quality, both dated June 2003, are signed by all applicable parties (“Amendment Date”). The licensor in this agreement is now Roche Palo Alto LLC, formerly Syntex (U.S.A.) Inc.

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SYNTEX (U.S.A.) INC. - AMERICAN HOME PRODUCTS CORPORATION SUBLICENSE AND SUPPLY AGREEMENT DATED SEPTEMBER 1, 1993 RE: NICARDIPINE IV
Sublicense and Supply Agreement • May 10th, 2005 • Protein Design Labs Inc/De • Biological products, (no disgnostic substances) • California

This AGREEMENT is made to be effective as of September 1, 1993 (the “effective date”), by and between American Home Products Corporation (“AMPC”), a corporation organized and existing under the laws of the State of Delaware, acting by the through its Wyeth-Ayerst Laboratories Division (“Wyeth-Ayerst”), having a mailing address at P.O. Box 8299, Philadelphia, Pennsylvania 19101, and syntex (U.S.A.) Inc., a corporation organized and existing under the laws of the State of Delaware, having a business address at 3401 Hillview Avenue, Palo Alto, California 94304 (“Syntex”).

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