0001104659-05-047257 Sample Contracts

METABASIS THERAPEUTICS, INC. WARRANT TO PURCHASE COMMON STOCK
Warrant Agreement • October 5th, 2005 • Metabasis Therapeutics Inc • Pharmaceutical preparations • California

This Certifies That, for value received, [ ], or assigns (the “Holder”), is entitled to subscribe for and purchase at the Exercise Price (defined below) from Metabasis Therapeutics, Inc., a Delaware corporation, with its principal office at 9390 Towne Centre Drive, Building 300, San Diego, California 92121 (the “Company”) up to [ ] shares of the common stock of the Company, par value $0.001 per share (the “Common Stock”).

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METABASIS THERAPEUTICS, INC. SECURITIES PURCHASE AGREEMENT SEPTEMBER 30, 2005
Securities Purchase Agreement • October 5th, 2005 • Metabasis Therapeutics Inc • Pharmaceutical preparations • California

THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made as of September 30, 2005, by and among METABASIS THERAPEUTICS, INC., a Delaware corporation (the “Company”) with its principal office at 9390 Towne Centre Drive, Building 300, San Diego, California 92121, and the individuals and entities identified on the signature pages hereto (the “Purchasers”).

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